Epitopes identification of broadly neutralizing monoclonal antibodies against Corynebacterium diphtheriae exotoxin
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Date
2022
Authors
Kulyk, Ya.
Siromolot, Andriy
Kolybo, Denys
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Abstract
Better and high-potency vaccines against diphtheria are urgently needed to provide broader protection against diverse strains and subtypes. Identification of novel broadly neutralizing epitopes targeted by protective antibodies could aid in such efforts. Aim. In this study we focused on the search of binding sites identification of anti diphtheria toxin monoclonal antibodies and their neutralizing activity to block binding of recombinant exotoxin derivates with host receptors.
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Keywords
diphtheria toxin, CRM197, SbB, monoclonal antibodies, proHB-EGF, epitopes mapping, neutralizing antibody, article
Citation
Kulyk Ya. S. Epitopes identification of broadly neutralizing monoclonal antibodies against Corynebacterium diphtheriae exotoxin / Kulyk Ya. S., Siromolot A. A., Kolybo D. V. // Biotechnologia Acta. - 2022. - Vol. 15, No. 4. - P. 37-40. - https://doi.org/10.15407/biotech15.04.037