Факультет природничих наук
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Item Association of alpha-synuclein co-pathology with beta-amyloid and phosphorylated tau levels in Alzheimer's disease(2025) Shpylchyn, Vitalii; Vyniavska, PolinaMisfolded α-synuclein (α-syn) aggregates can be present in the cerebrospinal fluid (CSF) of individuals with Alzheimer’s disease (AD), even in the absence of clinical signs of synucleinopathy. This co-pathology may influence AD progression at the molecular level. Detection of α-synuclein aggregates using seed amplification assay (SAA) enables stratification of AD patients beyond classical biomarkers included in the AT(N) framework. The AT(N) framework allows biological classification of AD based on its core pathological processes: β-amyloid aggregation (A), tau accumulation and hyperphosphorylation (T), and non-specific neurodegeneration (N). This study aimed to explore whether α-syn co-pathology, detected by SAA, is associated with altered concentrations and longitudinal trajectories of CSF β-amyloid 42 (Aβ42) and phosphorylated tau 181 (p-tau181) in the biomarker-defined AD group. Data from A+T+ participants (N = 609) in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analysed, using Roche Elecsys electrochemiluminescence immunoassay (ECLIA) and SAA results. Substantial discrepancies between clinical diagnosis and AT profiles were observed. Twenty-nine percent of A+T+ participants were α-synpositive (S+), indicating a high prevalence of α-syn co-pathology in biologically defined AD. Cross-sectional comparisons revealed that S+ individuals had lower baseline Aβ42 concentrations compared to α-synnegative (S−) participants. Linear mixed-effects models (LMEMs) showed a significantly steeper decline in Aβ42 over time in the S+ group, supporting the hypothesis that misfolded α-syn aggregation accelerates amyloid aggregation. However, p-tau181 levels increased more slowly in S+ than in S− individuals, contrary to expectations. These associations remained significant after adjustment for age, sex, diagnosis, and APOE-ε4 genotype. These findings suggest that α-syn co-pathology may affect AD progression through its interaction with Aβ42 and support its integration into biomarker-based classification frameworks.Item Communication of superoxide dismutase, catalase, reduced glutathione with antioxidant processes during human aging(2018) Kurytsia, K.; Romanenko, M.; Shapoval, I.Abstract of the XIV International scientific conference for students and PhD students,Youth and progress of biology, dedicated to the 185th anniversary from the birthday of B. Dybowski (Lviv, April 10-12, 2018).Item Diagnostics of entrepreneurial activity in Ukraine in the context of information support for sustainable development of territories(2024) Dymchenko, Olena; Smachylo, Valentyna; Rudachenko, Olha; Tararuiev, Iurii; Biletska, MarharytaThe relevance of the research topic is due to the need to use the tools of economic diagnostics to identify problems of entrepreneurship development in the regions of Ukraine and develop measures for state support of the private sector of the economy, which is especially important in the context of overcoming the consequences of hostilities and ensuring sustainable development of territories. In view of this, the aim of the article is to formulate recommendations for diagnosing the level of entrepreneurship development in the regions of Ukraine in the context of information support for sustainable development of territories. To achieve this goal, the article substantiates the criteria that characterize the regions of Ukraine, considering the main factors of entrepreneurship development. To generalize the primary information, the work uses the method of normalization, which made it possible to apply the method of integral assessment and determine the integral indicator of entrepreneurship development for each region. According to the results of the ranking of regions according to this criterion, the article identifies both regions with high business activity of business entities (Dnipropetrovsk, Kyiv, Lviv, Odesa and Kharkiv) and those that need state support in the field of organization of entrepreneurial activity (Ternopil, Sumy, Rivne, Chernihiv, Kherson, Chernivtsi, and Luhansk). According to the results of the study, a high level of disproportionality of entrepreneurship development in the regions of Ukraine has been identified, which is due to the centralization of financial, material, and intellectual resources at the present stage of development of the State. In practice, the key results of the study can be the basis for the development and improvement of the strategy for the development of entrepreneurship in Ukraine at the regional level. The article also formulates the most important promising directions for studying the problems of entrepreneurship development at the regional level using methods of economic diagnostics in the context of sustainable development.Item Dropout as a Bayesian Approximation(2017) Grytsenko, О.; Karpa, S.Тези учасника Шостої всеукраїнської конференції молодих вчених з математики та фізики, Київ, 21–22 квітня 2017 рік.Item Excitation and emission spectra of polyvinylpyrrolidone/ZnO nanocomposites with various interfaces(2017) Rudko, Galyna; Fediv, Volodymyr; Gule, Evgen; Isaieva, Oksana; Petrova, Kh. V.Presentation speech at the International Research and Practice Conference "Nanotechnology and Nanomaterials" (NANO-2017), 23-26 August 2017, Chernivtsi, Ukraine.Item Long non-coding RNA SNHG1 as a diagnostic and prognostic marker of bladder cance(2025) Bratyshchenko, Anastasiia; Haviaz, Volodymyr; Honcharenko, Anton; Stakhovsky, Eduard; Kononenko, Oleksiy; Rosohatska, Inna; Pasichnyk, Tetiana; Mankovska, OksanaBladder cancer (BC) is one of the most prevalent cancers globally, and it ranks as the fifth most common malignancy among men in Ukraine. Modern diagnostic tools for bladder cancer have significant limitations: some of them are overly invasive and others lack sufficient sensitivity and specificity. Currently, molecular markers are becoming a promising tool for identification of oncogenic processes. Among epigenetic mechanisms involved in malignant cell transformation, long non-coding RNA (lncRNA)s are of particular interest, as they can act as either oncogenes or tumor suppressors. Available studies suggest that the lncRNA SNHG1, which is currently understudied, promotes tumor proliferation and inhibits apoptosis in malignant cells. The aim of the current study was to analyze changes in the relative expression of SNHG1 in tumor tissues and its levels in cell-free urine of bladder cancer patients, and to evaluate its diagnostic and prognostic value. There was a statistically significant increase in the SNHG1 gene expression level in tumor tissues compared to conditionally normal tissues. Also, a significant decrease in relative levels of SNHG1 transcripts was observed in urine of BC patients compared to healthy individuals. According to the analysis of ROC curves analysis, the chosen marker can identify bladder cancer with high sensitivity and specificity. A positive correlation was also discovered between SNHG1 expression level in tumor tissue and cancer stage. The obtained data support the relevance of further study on lncRNA SNHG1 as a promising diagnostic and prognostic marker of bladder cancer.Item Protein aggregates carry non-genetic memory in bacteria after stresses(2020) Kukharenko, O.; Terzova, Vitaliia; Zubova, G.Protein aggregation is related to the formation of oligomers and aggregates, leading to impaired cellular processes. The protein aggregates formation is associated with pathologies and ageing in eukaryotes whereas in bacteria aggregation causes dramatic changes in growth rate, stress resistance and virulence, and eventually these aggregates play a functional role. Both cellular and environmental factors enhance protein damage via aggregation, nonetheless, upon sublethal doses of proteotoxic environmental stressors, protein aggregates may improve cellular robustness and carry a type of non-genetic memory of the previous stressors through several generations. Emerging data on aggregated proteins, carrying non-genetic (epigenetic) traits, show that protein-based inheritance is known within all three kingdoms of living organisms. This review focuses on the protein aggregates as carriers of non-genetic memory in bacteria.Item Removal of heavy metal ions from water using combination of functionalized silicas with membranes(2017) Sliesarenko, V.; Fetisova, Yu.; Dudarko, O.; Zub, Yu.Presentation speech at the International Research and Practice Conference "Nanotechnology and Nanomaterials" (NANO-2017), 23-26 August 2017, Chernivtsi, Ukraine.Item The significance of urban conservation areas for the preservation of migratory birds in Scotland (a case study of Glasgow)(2024) Dzhuma, Veronika; Derevska, Kateryn; Klestov, MykolaThis study looks at avian variety of three urban parks in Glasgow, Scotland, and highlights the significance of such green places for biodiversity protection. The study identified a number of bird species, both common and rare, and linked their presence to ecological parameters like adaptation, diet, distribution, and migratory behaviour. The different habitats within the parks were discovered to be critical for avian biodiversity and providing stopover areas for migrating birds.Item Study of guanidine-containing oligomer for desinfectant application(2025) Hodlevskyi, H.; Hudyma, A.; Vakuliuk, Polina; Pryshchepa, Oleksandra; Furtat, Iryna; Vortman, Maryna; Fijalkowski, Pawel; Rafińska, K.; Lemeshko, Valentyna; Murlanova, Tetiana; Smarsly, Bernd; Pomastowskі, Paweł; Shevchenko, V.The purpose of this project is a creation of guanidine containing oligomer, that could be used as a disinfectant against multiresistant microorganisms.Item Synthesis of mesoporous materials for extraction of heavy and rare-earth metal ions(2016) Dudarko, O.; Gaidai, Alina; Sliesarenko, V.; Prybora, N.; Zub, Yu.The material of the speech at Ukrainian conference with international participation "Chemistry, physics and technology of surface" devoted to the 30th anniversary of the founding of Chuiko Institute of Surface Chemistry of NAS of Ukraine and Workshop "Nanostructured biocompatible / bioactive materials" (17-18 May 2016, Kyiv, Ukraine).Item Visible photoluminescence of aged Zn(acac)2/C2H5OH solution: emission/excitation/kinetics study(2017) Vasin, A.; Kysil, D.; Rudko, Galyna; Isaieva, OksanaPresentation speech at the International Research and Practice Conference "Nanotechnology and Nanomaterials" (NANO-2017), 23-26 August 2017, Chernivtsi, Ukraine.Item Ways and opportunities for utilizing Danube ports in the context of european integration(2024) Horoshkova, Lidiіa; Horoshkov, Stanislav; Korniichuk, YuliiaМатеріали доповіді учасників ІV Міжнародної науково-практичної конференції "Боголібські читання", 2024.Item Алгоритми розв'язання задач великої розмірності з розрідженою матрицею на прикладі моделі Леонтьєва-Форда(2017) Журавель, І.Тези учасника Шостої всеукраїнської конференції молодих вчених з математики та фізики, Київ, 21–22 квітня 2017 рік.Item Борелівські ігри оптимального знаходження у стані(2017) Мороз, В.Тези учасника Шостої всеукраїнської конференції молодих вчених з математики та фізики, Київ, 21–22 квітня 2017 рік.Item Біомаркери селезінки Ящірки зеленої(2017) Дунаєвська, О.; Васильченко, В.; Кучменко, О.Матеріал виступу на VІІІ Всеукраїнській науково-практичній конференції з міжнародною участю "Біологічні дослідження - 2017", 14-16 березня 2017 р.Item Використання засобів фізичної культури та спорту при цукровому діабеті 1-ого типу(2018) Кривошеєнко, Юлія; Козубей, ПетроТези доповіді на XV Всеукраїнській науковій конференції студентів і молодих вчених "Молодь: освіта, наука, духовність" ("Youth: education, science, spirituality"), м. Київ, 17-19 квітня 2018 p.Item Використання засобів фізичної культури та спорту у профілактиці та лікуванні сколіозу(2018) Чумаченко, Олександра; Козубей, ПетроТези доповіді на XV Всеукраїнській науковій конференції студентів і молодих вчених "Молодь: освіта, наука, духовність" ("Youth: education, science, spirituality"), м. Київ, 17-19 квітня 2018 p.Item Використання засобів фізичної реабілітації при цукровому діабеті(2020) Грачова, Катерина; Лахманюк, ТетянаМета дослідження - визначення важливості використання фізичних вправ у профілактиці та лікуванні цукрового діабету першого типу та їхнього впливу на подальше протікання хвороби.Item Властивості періодичних біотопних просторів(2017) Яворський, Р.Тези учасника Шостої всеукраїнської конференції молодих вчених з математики та фізики, Київ, 21–22 квітня 2017 рік.
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