Наукові записки НаУКМА. Біологія та екологія

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Періодичне фахове видання "Наукові записки НаУКМА. Біологія та екологія" є друкованим засобом масової інформації, науковим рецензованим журналом відкритого доступу, що оприлюднює статті з біологічної та екологічної проблематики.

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Browsing Наукові записки НаУКМА. Біологія та екологія by Author "Lemeshko, Valentyna"

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    The effectiveness of surfactants as compounds for creating disinfectants with a wide spectrum of action
    (Національний університет "Києво-Могилянська академія", 2024) Nechypurenko, Oleksii; Furtat, Iryna; Vakuliuk, Polina; Lemeshko, Valentyna; Vortman, Maryna; Shevchenko, Valerii
    Along with the use of antibiotics, the use of disinfectants is crucial in the fighting against multi-resistant strains of bacteria that are dangerous not only for animals but also for humans. A new complex disinfectant could be used as a prevention method. Therefore, the aim of the work was to evaluate the effectiveness surfactants (anionic, cationic and non-ionic) as compounds for the creating of disinfectants with a wide spectrum of action. Compositions with guanidine-containing oligomer (GCO) inhibited S. aureus and C. albicans most effectively. At concentrations of 1000 and 100 ppm, 100 % of cells were inactivated. The biocidal effect against representatives of Gram-negative bacteria was weaker, which should be considered during creation of antimicrobial agents active against pathogenic strains of E. coli. With a rational combination of effective components and their synergism, it is possible to significantly reduce the concentration of the working solution compared to already used commercial disinfectants. For example, the concentration of glutaraldehyde in composition containing 3 % GCO, 1 % Triton X-100, 1 % Trilon B and 1 % glutaraldehyde was in 9 times lower than of Lysoformin 3000. Also, most surfactants used were not characterized by mutagenic activity, which is one of the main criteria for disinfectants usage since this reduces the risks of developing bacterial resistance to antibiotics and other biocides. Thus, the development and implementation of new disinfectants, which could help to fight against multi-resistant strains of bacteria, is an indispensable part of comprehensive programs in controlling and prevention of common diseases in animal husbandry and medicine, particularly, colibacillosis.