Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5-12 Weeks of Gestation

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dc.contributor.authorSorochynska, Khrystyna
dc.contributor.authorSych, Nataliia
dc.contributor.authorDuda, Alla
dc.contributor.authorKulebyakina, Kateryna
dc.contributor.authorKrasnienkov, Dmytro
dc.contributor.authorVaiserman, Alexander
dc.contributor.authorVatlitsov, Denys
dc.date.accessioned2019-05-15T09:23:43Z
dc.date.available2019-05-15T09:23:43Z
dc.date.issued2018
dc.description.abstractFetal stem cell- (FSC-) based therapy is a promising treatment option for many diseases. The differentiation potential of FSCs is greater than that in adult stem cells, and they are more tissue-specific and have lower immunogenicity and better intrinsic homing than embryonic ones. Embryonic stem cells have higher proliferative potential than FSCs but can cause teratomas. Therefore, an evaluation of this potential represents an important biomedical challenge. Since regulation of telomere length (TL) is one mechanism governing cellular proliferation, TL is a useful surrogate marker for cell replicative potential. The prenatal dynamics of TL, however, has never been comprehensively studied. In the present study, dynamics of TL and telomerase activity in the human fetal liver during 5–12 weeks of gestation is examined. Both TL and telomerase activity were positively correlated with week of gestation. For both parameters studied, the trend to increase was evident up to 10th week of gestation. After that, they reached a plateau and remained stable. These findings indicate that telomerase activity remains high during the fetal stage, suggesting high replicative capacity of FSCs and their considerable potential for transplantation therapies. These findings, however, are preliminary only due to small sample size and require further evaluation.en_US
dc.identifier.citationDynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5-12 Weeks of Gestation / K. Sorochynska, N. Sych, A. Duda [et al.] // Stem Cells International. - 2018. - [7] p.en_US
dc.identifier.issn1687-966X
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/15562
dc.identifier.urihttps://doi.org/10.1155/2018/1385903
dc.language.isoenen_US
dc.relation.sourceStem Cells Internationalen_US
dc.statuspublished earlieren_US
dc.subjecttelomere lengthen_US
dc.subjecttelomerase activityen_US
dc.subjectBiologyen_US
dc.subjecthuman fetal liveren_US
dc.subjectgestationen_US
dc.subjectarticleen_US
dc.titleDynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5-12 Weeks of Gestationen_US
dc.typeArticleen_US
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