Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5-12 Weeks of Gestation
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Date
2018
Authors
Sorochynska, Khrystyna
Sych, Nataliia
Duda, Alla
Kulebyakina, Kateryna
Krasnienkov, Dmytro
Vaiserman, Alexander
Vatlitsov, Denys
Journal Title
Journal ISSN
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Abstract
Fetal stem cell- (FSC-) based therapy is a promising treatment option for many diseases. The differentiation potential of FSCs is
greater than that in adult stem cells, and they are more tissue-specific and have lower immunogenicity and better intrinsic
homing than embryonic ones. Embryonic stem cells have higher proliferative potential than FSCs but can cause teratomas.
Therefore, an evaluation of this potential represents an important biomedical challenge. Since regulation of telomere length (TL)
is one mechanism governing cellular proliferation, TL is a useful surrogate marker for cell replicative potential. The prenatal
dynamics of TL, however, has never been comprehensively studied. In the present study, dynamics of TL and telomerase activity
in the human fetal liver during 5–12 weeks of gestation is examined. Both TL and telomerase activity were positively correlated
with week of gestation. For both parameters studied, the trend to increase was evident up to 10th week of gestation. After that,
they reached a plateau and remained stable. These findings indicate that telomerase activity remains high during the fetal stage,
suggesting high replicative capacity of FSCs and their considerable potential for transplantation therapies. These findings,
however, are preliminary only due to small sample size and require further evaluation.
Description
Keywords
telomere length, telomerase activity, Biology, human fetal liver, gestation, article
Citation
Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5-12 Weeks of Gestation / K. Sorochynska, N. Sych, A. Duda [et al.] // Stem Cells International. - 2018. - [7] p.