Estimation of hematopoietic progenitor cells in patients with chronic myeloid leukemia with resistance to tyrosine kinase inhibitors

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dc.contributor.authorBilko, Nadiyaen_US
dc.contributor.authorDyagil, Irynaen_US
dc.contributor.authorRussu, Irynaen_US
dc.date.accessioned2026-02-20T06:22:07Z
dc.date.available2026-02-20T06:22:07Z
dc.date.issued2023
dc.description.abstractChronic myeloid leukemia (CML) is a clonal oncological disease associated with the formation of chimeric bcr-abl gene, the product of which is active BCR-ABL tyrosine kinase playing a major role in the pathogenesis of CML. Data obtained in recent years allowed to assume the decisive role not only of hematopoietic stem cells, but also of bone marrow (BM) progenitor cells in both onset and progression of the disease. However, information on the functional characteristics of BM hematopoietic progenitor cells in different CML phases, in terms of therapeutic inhibition of BCR-ABL tyrosine kinase and the resistance to Imatinib, is not sufficient today and some findings are contradictory. Hence, the aim of this investigation was the estimation of BM hematopoietic progenitor cells in patients with CML with the resistance to tyrosine kinase inhibitors, using in vitro cell culture.en_US
dc.identifier.citationBilko N. M. Estimation of hematopoietic progenitor cells in patients with chronic myeloid leukemia with resistance to tyrosine kinase inhibitors / N. Bilko, I. Dyagil, I. Russu // XXIII. Wilsede Meeting on Modern Trends in Human Leukaemia and Cancer June 24-27, 2023, Wilsede, Germany : abstract book. - [S. l. : s. n.], 2023. - P. 68.en_US
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/38393
dc.language.isoenen_US
dc.relation.sourceXXIII. Wilsede Meeting on Modern Trends in Human Leukaemia and Cancer June 24-27, 2023, Wilsede, Germany : abstract booken_US
dc.statusfirst publisheden_US
dc.subjectChronic myeloid leukemia (CML)en_US
dc.subjectchimeric bcr-ablen_US
dc.subjecthematopoietic stem cellsen_US
dc.subjectvitro cell cultureen_US
dc.subjectconference materialsen_US
dc.titleEstimation of hematopoietic progenitor cells in patients with chronic myeloid leukemia with resistance to tyrosine kinase inhibitorsen_US
dc.typeConference materialsen_US
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