Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats

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dc.contributor.authorSnezhkova, Elisaveta
dc.contributor.authorRodionova, Natalia
dc.contributor.authorBilko, Denys
dc.contributor.authorSilvestre-Albero, JoaquĆ­n
dc.contributor.authorSydorenko, Alexey
dc.contributor.authorYurchenko, Olga
dc.contributor.authorPakharenko, Marharyta
dc.contributor.authorAlavijeh, Mohammad
dc.contributor.authorBardakhivska, Kvitoslava
dc.contributor.authorRiabchenko, Natalia
dc.contributor.authorNikolaev, Volodymyr
dc.date.accessioned2021-11-16T21:41:26Z
dc.date.available2021-11-16T21:41:26Z
dc.date.issued2021
dc.description.abstractActivated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment.en
dc.identifier.citationOrally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats [electronic resource] / Snezhkova E., Rodionova N., Bilko D., Silvestre-Albero J., Sydorenko A., Yurchenko O., Pakharenko M., Alavijeh M., Bardakhivska K., Riabchenko N., Nikolaev V. // Applied Sciences : open access journal. - 2021. - Vol. 11, Issue 7. - Article number 3174.en
dc.identifier.urihttps://doi.org/10.3390/app11073174
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/21553
dc.language.isoenuk_UA
dc.relation.sourceApplied Sciences : open access journal.ru
dc.statusfirst publisheduk_UA
dc.subjectactivated charcoalen
dc.subjectenterosorbenten
dc.subjectacute radiation sicknessen
dc.subjectratsen
dc.subjectarticleen
dc.titleOrally administered activated charcoal as a medical countermeasure for acute radiation syndrome in ratsen
dc.typeArticleuk_UA
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