Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats

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Date
2021
Authors
Snezhkova, Elisaveta
Rodionova, Natalia
Bilko, Denys
Silvestre-Albero, Joaquín
Sydorenko, Alexey
Yurchenko, Olga
Pakharenko, Marharyta
Alavijeh, Mohammad
Bardakhivska, Kvitoslava
Riabchenko, Natalia
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Abstract
Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment.
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Keywords
activated charcoal, enterosorbent, acute radiation sickness, rats, article
Citation
Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats [electronic resource] / Snezhkova E., Rodionova N., Bilko D., Silvestre-Albero J., Sydorenko A., Yurchenko O., Pakharenko M., Alavijeh M., Bardakhivska K., Riabchenko N., Nikolaev V. // Applied Sciences : open access journal. - 2021. - Vol. 11, Issue 7. - Article number 3174.