Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats
Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment.
activated charcoal, enterosorbent, acute radiation sickness, rats, article
Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats [electronic resource] / Snezhkova E., Rodionova N., Bilko D., Silvestre-Albero J., Sydorenko A., Yurchenko O., Pakharenko M., Alavijeh M., Bardakhivska K., Riabchenko N., Nikolaev V. // Applied Sciences : open access journal. - 2021. - Vol. 11, Issue 7. - Article number 3174.