183: Хімічні науки і технології

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Entrapment modification of the polyacrylamide gel with chitosan polymers for the purposes of surface activation for tissue engineering
(2016) Bilko, Denys; Borodulin, Y.; Antoniuk, N.; Kolesnyk, Iryna; Burban, Anatoliy
In recent years hydrogels have become attractive targets for development of the controlled release rate substances that are characterized by suitable chemical and physical properties. Recent advances in the tissue engineering and cell therapy technologies have introduced additional value to the biologically compatible hydrogels that could be chemically modified with specific factors, such as cell microenvironment proteins, allowing for shaping and controlled growth of the cells in the 3D formations, suitable for further tissue engineering and cell therapy. This paper reports a mechanism of the entrapment modification of the polyacrylamide based gels with chitosan polymer. Such modification allows for the further covalent crosslinking of the protein-based growth factors and other extracellular matrix proteins that fully support proliferation and maintenance of the adhesion dependent and adhesion independent cells, including hematopoietic and mesenchymal stem cells.