Докторська школа імені родини Юхименків

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Browsing Докторська школа імені родини Юхименків by Author "Konovalova, Viktoriia"

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    Development of the technology and research of hydrogel with the combination of alginate and ethonium for immediate release drug delivery systems
    (2024) Sikach, Alina; Konovalova, Viktoriia
    The purpose of this study was to develop a technology for obtaining hydrogel systems for the immediate release of drugs and to study the kinetics of the release of a bactericidal drug to facilitate the healing process of open wounds. For this, sodium alginate, partially hydrophobized sodium alginate, anhydrous calcium chloride and sodium carbonate were used.
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    Enhancing of transport parameters and antifouling properties of PVDF membranes modified with Fe3O4 nanoparticles in the process of proteins fractionation
    (2023) Bubela, Halyna; Konovalova, Viktoriia; Kujawa, Joanna; Kolesnyk, Iryna; Burban,Anatoliy; Kujawsk, Wojciech
    Polyvinylidene fluoride membranes were modified using polyethyleneimine with subsequent immobilization of Fe3O4 nanoparticles. FTIR spectroscopy was utilized to confirm the modification process. A table with observed bands and their assignments was presented for better understanding and avoiding an unproven interpretation of peaks.
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    Fabrication of polyelectrolyte complexes based on natural polysaccharides for potential drug-delivery systems
    (2024) Sikach, Alina; Konovalova, Viktoriia
    Polyelectrolyte complexes are materials based on polyelectrolytes with the opposite charge, which, as a rule, are soluble in water. The interaction between polyelectrolytes with the opposite charge leads to the formation of an insoluble substance that can turn into a solid in an aqueous medium. Such a process occurs without the use of organic solvents and is initiated by the dissolution of salt in water, causing the complexation of polyelectrolytes by adjusting pH or salinity.
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    Fabrication of PSS-PDADMAC membranes via salt dilution-induced aqueous phase separation
    (2024) Sikach, Alina; Konovalova, Viktoriia
    Polyelectrolyte complex membranes are materials based on oppositely charged polyelectrolytes that are typically soluble in water. Interaction between oppositely charged polyelectrolytes creates an insoluble substance that can form solids in aqueous environments. Such a process does not require organic solvents, and such an aqueous salt-dilution-induced phase separation process induces polyelectrolyte complexation through a pH or salinity switch [1]. Due to the low dielectric constant polyelectrolyte complex membranes are stable in organic solvents, which makes them suitable for a wider range of separation processes [2]. In this study membranes based on poly (sodium 4-styrene sulfonate) (PSS) and poly (diallyl dimethyl ammonium chloride) (PDADMAC) were obtained using the method proposed by J. Kamp et al. [1]. The investigation focused on assessing the impact of polymer concentration and forming knife thickness on the membrane properties.
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    Formation Of PSS-PDADMAC Membranes Based On Salt Dilution-Induced Aqueous Phase Separation
    (2023) Sikach, Alina; Konovalova, Viktoriia
    In these study membranes based on Poly (sodium 4-styrene sulfonate) (PSS) and Poly (diallyl dimethyl ammonium chloride) (PDADMAC) were obtained by the method proposed by J. Kamp et al. [1]. The membrane preparation is based on interpolymer complexes formation in a water medium. The influence of the concentration of polymers (20 and 25 wt. %) and the thickness of the forming knife (200 and 400 μm) on the morphological properties of the formed membranes were studied. It was established that the average pore size for membranes based on 25% solutions is higher (107 ± 4 nm) than for 20% solutions (94 ± 3 nm). The pore structure in the samples is spongy (Fig.1) and does not depend on concentration or thickness.
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    Hydrogel films based on modified alginate as a base for personalized antibacterial wound treatment
    (2023) Sikach, Alina; Konovalova, Viktoriia
    Materials based on natural polysaccharides are increasingly used for innovative wound dressings which have more extensive requirements that current medical products on the market cannot provide [1]. The issue of open wounds treatment became crucial in Ukraine due to the ongoing war, necessitating wound dressings that provide mechanical, antibacterial protection, and accelerate healing process. In this work, ethonium-containing hydrogel films were developed using partially hydrophobized alginate (AlgM) unmodified alginate (Alg) and 1:1 mixture of Alg and AlgM (Alg+AlgM). These films were studied to determine the effect of alginate modification on ethonium release kinetics.
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    The influence of alginate modification on the morphological structure of alginate-based films with immobilized ethonium
    (2023) Sikach, Alina; Konovalova, Viktoriia
    Тези доповіді учасників Міжнародної конференції з хімії, хімічної технології та екології, присвячена 125-річчю КПІ ім. Ігоря Сікорського, 26-29 вересня 2023 р., Київ, Україна.