Кафедра лабораторної діагностики біологічних систем
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Browsing Кафедра лабораторної діагностики біологічних систем by Author "Bilko, Nadiya"
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Item Assessments of radionuclides influence on Wistar rats' hematopoietic system using cell culture in vivo(Видавництво ЧНУ ім. Петра Могили, 2025) Russu, Iryna; Bilko, NadiyaThe aim of this work is determination of the influence of radionuclides strontium-90 and iodine-131 on the hematopoietic system of Wistar rats, after single and long-term internal exposure to ionizing radiation.Item Estimation of hematopoietic progenitor cells in patients with chronic myeloid leukemia with resistance to tyrosine kinase inhibitors(2023) Bilko, Nadiya; Dyagil, Iryna; Russu, IrynaChronic myeloid leukemia (CML) is a clonal oncological disease associated with the formation of chimeric bcr-abl gene, the product of which is active BCR-ABL tyrosine kinase playing a major role in the pathogenesis of CML. Data obtained in recent years allowed to assume the decisive role not only of hematopoietic stem cells, but also of bone marrow (BM) progenitor cells in both onset and progression of the disease. However, information on the functional characteristics of BM hematopoietic progenitor cells in different CML phases, in terms of therapeutic inhibition of BCR-ABL tyrosine kinase and the resistance to Imatinib, is not sufficient today and some findings are contradictory. Hence, the aim of this investigation was the estimation of BM hematopoietic progenitor cells in patients with CML with the resistance to tyrosine kinase inhibitors, using in vitro cell culture.Item Functional activity of hematopoietic stem and progenitor cells under the acute and chronic exposure to ionizing radiation in different doses(2021) Russu, Iryna; Bilko, NadiyaThe aim of the current study was investigation of functional properties of hematopoietic stem and progenitor cells of Balb/C mice under external acute and chronic exposure to irradiation in different doses.