Development of a dietary supplement for improving the cognitive and lowering the homocysteine level

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dc.contributor.authorRomaniuk, Svitlana
dc.contributor.authorTykhonenko, Tetiana
dc.contributor.authorSiromolot, Andriy
dc.contributor.authorGuzyk, Mykhailo
dc.contributor.authorLugovska, Natalia
dc.contributor.authorGalkin, Olexander
dc.contributor.authorKuchmerovska, Tamara
dc.contributor.authorKolybo, Denys
dc.contributor.authorKomisarenko, Sergiy
dc.date.accessioned2023-04-19T08:45:03Z
dc.date.available2023-04-19T08:45:03Z
dc.date.issued2022
dc.description.abstractPurpose. To develop the dietary supplement for reducing high homocysteine levels, which has a minimum content of components that may cause side effects; to test the supplement effect on the cognitive abilities of ani-mals and to commercialize the product.Materials and Methods. The developed dietary supplement Alfacognitin contains vitamins B6, B9, B12, C, and choline. For modelling experimental hyperhomocysteinemia in rats, the animals are kept on a diet rich in L-methionine. Blood homocysteine concentrations are determined by the ion exchange liquid column chromato-graphy method with the use of an automatic amino acid analyzer. The behavioral responses and cognitive abilities of the rats have been studied with the use of behavioral tests (open field test, fear conditioning test, and social int e raction test). The production of Alfacognitin dietary supplement has been launched with Nutrimed Ltd. (Kyiv).en_US
dc.identifier.citationDevelopment of a dietary supplement for improving the cognitive and lowering the homocysteine level / Romaniuk S. I., Tykhonenko T. M., Siromolot A. A., Guzyk M. M., Lugovska N. E., Galkin O. Yu., Kuchmerovska Т. М., Kolybo D. V., Komisarenko S. V. // Science and Innovation. - 2022. - Vol. 18, No. 1. - P. 66-75. - https://doi.org/10.15407/scine18.01.066en_US
dc.identifier.issn2409-9066
dc.identifier.issn2413-4996
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/25063
dc.identifier.urihttps://doi.org/10.15407/scine18.01.066
dc.language.isoen
dc.relation.sourceScience and Innovationen_US
dc.statusfirst publisheden_US
dc.subjecthyperhomocysteinemiaen_US
dc.subjectdietary supplementen_US
dc.subjectvitamins Ben_US
dc.subjectvitamin Cen_US
dc.subjectcholineen_US
dc.subjectcardiovascular diseasesen_US
dc.subjectcognitive functionsen_US
dc.subjectCOVID-19en_US
dc.subjectarticleen_US
dc.titleDevelopment of a dietary supplement for improving the cognitive and lowering the homocysteine levelen_US
dc.title.alternativeРозроблення засобу для покращення когнітивних функцій та зниження рівня гомоцистеїнуuk_UA
dc.typeArticleen_US
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