The oxidative status in patients with chronic kidney disease

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dc.contributor.authorVasylchenko, V.
dc.contributor.authorKorol, L.
dc.contributor.authorKuchmenko, Olena
dc.contributor.authorStepanova, N.
dc.date.accessioned2021-03-24T23:15:16Z
dc.date.available2021-03-24T23:15:16Z
dc.date.issued2020
dc.description.abstractAn excess of free radicals accompanies the development of renal pathologies and causes numerous concomitant complications and syndromes. The most common of these are cardiometabolic syndromes in patients with chronic kidney disease. Therefore, the purpose of the study was to determine the activity of paraoxonase-1 and myeloperoxidase, which are associated with indicators of high-density lipoproteins content and oxidative stress in the blood of patients with the chronic stage of kidney disease. The activity of the enzymes, thiobarbiturate-active products concentration and transferrin, ceruloplasmin, thiol compounds content were determined in the blood of patients with chronic kidney disease. The oxidative status was shown to be changed. Thus, myeloperoxidase activity, the content of oxidized proteins and the concentration of thiobarbiturate-positive components were increased, while the activity of the antioxidant enzyme paraoxonase-1, the content of transferrin, ceruloplasmin and thiol compounds were decreased. The ratio of myeloperoxidase / paraoxonase-1 activities was progressively increased up to 9-fold, indicating the presence of cardiovascular complications in patients. The data obtained allowed to extend the range of indicators for monitoring the development of cardiometabolic disorders in the progression of chronic kidney disease.en_US
dc.identifier.citationThe oxidative status in patients with chronic kidney disease [electronic resource] / V. S. Vasylchenko, L. V. Korol, O. B. Kuchmenko, N. M. Stepanova // Ukrainian Biochemical Journal. - 2020. - Vol. 92, Issue 5. - P. 70-77.en_US
dc.identifier.urihttps://doi.org/10.15407/ubj92.05.070
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/19673
dc.language.isoenuk_UA
dc.relation.sourceUkrainian Biochemical Journal.en_US
dc.statusfirst publisheduk_UA
dc.subjectoxidative statusen_US
dc.subjectparaoxonase-1en_US
dc.subjectmyeloperoxidaseen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectarticleen_US
dc.titleThe oxidative status in patients with chronic kidney diseaseen_US
dc.typeArticleuk_UA
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