Rational design of large flat nitrogen-doped graphene oxide quantum dots with green-luminescence suitable for biomedical applications

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dc.contributor.authorNazarkovsky, Michael
dc.contributor.authorMikhraliieva, Albina
dc.contributor.authorAchete, Carlos
dc.contributor.authorAlves, Luiz Anastacio
dc.contributor.authorAraujo, Joyce
dc.contributor.authorArchanjo, Br´aulio
dc.contributor.authorFrança de Barros, Jos´e J´unior
dc.contributor.authorMonteiro da Fonseca Cardoso, Liana
dc.contributor.authorCouceiro, Jos´e Nelson
dc.contributor.authorMarques, Fernanda Davi
dc.contributor.authorOliveira, Bruno
dc.contributor.authorNascimento Dias de Souza, Rafael
dc.contributor.authorTeixeira, Ayla Josma
dc.contributor.authorVasconcelosb, Thiago
dc.contributor.authorZaitsev, Vladimir
dc.date.accessioned2022-10-25T10:24:04Z
dc.date.available2022-10-25T10:24:04Z
dc.date.issued2022
dc.description.abstractRational synthesis and simple methodology for the purification of large (35–45 nm in lateral size) and flat (1.0–1.5 nm of height) nitrogen-doped graphene oxide quantum dots (GOQDs) are presented. The methodology allows robust metal-free and acid-free preparation of N-GOQDs with a yield of about 100% and includes hydrothermal treatment of graphene oxide with hydrogen peroxide and ammonia. It was demonstrated that macroscopic impurities can be separated from N-GOQD suspension by their coagulation with 0.9% NaCl solution. Redispersible in water and saline solutions, particles of N-GOQDs were characterized using tip-enhanced Raman spectroscopy (TERS), photoluminescent, XPS, and UV-VIS spectroscopies. The size and morphology of N-GOQDs were studied by dynamic light scattering, AFM,SEM, and TEM. The procedure proposed allows nitrogen-doped GOQDs to be obtained, having 60–51% of carbon, 34–45% of oxygen, and up to 7.2% of nitrogen. The N-GOQD particles obtained in two hours of synthesis contain only pyrrolic defects of the graphene core. The fraction of pyridine moieties grows with the time of synthesis, while the fraction of quaternary nitrogen declines. Application of TERS allows demonstration that the N-GOQDs consist of a graphene core with an average crystallite size of 9 nm and an average distance between nearest defects smaller than 3 nm. The cytotoxicity tests reveal high viability of the monkey epithelial kidney cells Vero in the presence of N-GOQDs in a concentration below 60 mg L 1. The N-GOQDs demonstrate green luminescence with an emission maximum at 505 nm and sedimentation stability in the cell culture medium.en_US
dc.identifier.citationRational design of large flat nitrogen-doped graphene oxide quantum dots with green-luminescence suitable for biomedical applications / Michael Nazarkovsky, Albina Mikhraliieva, Carlos A. Achete, Luiz Anastacio Alves, Joyce Araujo, ... Vladimir Zaitsev // RSC Advances. - 2022. - Vol. 12, Issue 23. - Р. 14342-14355. - https://doi.org/10.1039/d2ra01516aen_US
dc.identifier.issn2046-2069
dc.identifier.urihttps://doi.org/10.1039/d2ra01516a
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/23923
dc.language.isoenuk_UA
dc.relation.sourceRSC Advancesen_US
dc.statusfirst publisheduk_UA
dc.subjectnitrogen-doped graphene oxideen_US
dc.subjectdynamic light scatteringen_US
dc.subjectthe cytotoxicity testsen_US
dc.subjectnitrogen-doped GOQDsen_US
dc.subjectcell culture mediumen_US
dc.subjectarticleen_US
dc.titleRational design of large flat nitrogen-doped graphene oxide quantum dots with green-luminescence suitable for biomedical applicationsen_US
dc.typeArticleuk_UA
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