Ornidazol-based application sorbent with nano silica and its antimicrobial activity

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dc.contributor.authorBilyayeva, Olga
dc.contributor.authorKarol, Ivan
dc.contributor.authorDemianenko, Eugeniy
dc.contributor.authorGaidai, Alina
dc.contributor.authorKryzhevskyi, Yevhenii
dc.contributor.authorVakuliuk, Polina
dc.contributor.authorGolub, Alexander
dc.date.accessioned2023-11-30T09:19:28Z
dc.date.available2023-11-30T09:19:28Z
dc.date.issued2023
dc.description.abstractThe aim: To investigate the effect of application sorbent based on ornidazole with nanosilicon in experiment and clinic. Materials and methods: In order to study the effectiveness of the Ornidasil application sorbent for the treatment of purulent wounds, we conducted an experimental study in rats. Also, we studied the effectiveness of the Ornidasil in the clinic for the treatment of patients with diabetic foot syndrome and to prevent the suppuration of postoperative wounds in patients with purulent peritonitis in toxic and terminal stages. Results: The formation of active substance complexes with hydroxylated matrices is due to hydrogen bonds between the oxygen atom of the silanol group of the silica surface and the hydrogen atom of the alcohol group of the ornidazole molecule. This promotes the gradual release of ornidazole from the surface of such a matrix into the wound exudate. Thus, on day 13, 9 experimental rats of group I healed completely, 11 rats had a small wound surface, complete healing occurred on day 15. We also investigated the effectiveness Ornidasil in the clinic. In the comparison group, postoperative wound suppuration occurred in 6 patients (31.6%), and in the main group - in 3 patients (12.5%). Conclusions: A study of the effectiveness Ornidasil in the complex treatment of Diabetic foot syndrome showed that in the experimental groups, wound healing occurred 1.6 -1.9 times faster. The use of polyurethane wound protector in combination with Ornidasil reduced the suppuration of postoperative wounds in patients of the main group by 2.5 times relative to patients in the comparison group.en_US
dc.identifier.citationOrnidazol-based application sorbent with nano silica and its antimicrobial activity / Olga Bilyayeva, Ivan Karol, Eugeniy Demianenko, Alina Gaidai, Yevhenii Kryzhevskyi, Polina Vakuliuk, Alexander Golub // Wiadomosci lekarskie. - 2023. - Vol. 76, Issue 6. - P. 1347-1358. - https://doi.org/10.36740/WLek202306104en_US
dc.identifier.issn0043-5147
dc.identifier.issn2719-342X
dc.identifier.urihttps://doi.org/10.36740/WLek202306104
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/27396
dc.language.isoenen_US
dc.relation.sourceWiadomosci lekarskiepl_PL
dc.statusfirst publisheduk_UA
dc.subjectornidazoleen_US
dc.subjectnano silicaen_US
dc.subjecthybrid nanocompositesen_US
dc.subjectquantum chemical calculationsen_US
dc.subjectin vivo therapeutic effecten_US
dc.subjectclinical studyen_US
dc.subjectarticleen_US
dc.titleOrnidazol-based application sorbent with nano silica and its antimicrobial activityen_US
dc.typeArticleuk_UA
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