Population Genomics of Stone Age Eurasia

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dc.contributor.authorAllentoft, Morten
dc.contributor.authorSikora, Martin
dc.contributor.authorAlba, Refoyo-Martínez
dc.contributor.authorEvan K. Irving-Pease
dc.contributor.authorFischer, Anders
dc.contributor.authorBarrie, William
dc.contributor.authorIngason, Andrés
dc.contributor.authorStenderup, Jesper
dc.contributor.authorSjögren, Karl-Göran
dc.contributor.authorPearson, Alice
dc.contributor.authorSousa da Mota, Bárbara
dc.contributor.authorSchulz Paulsson, Bettina
dc.contributor.authorHalgren, Alma
dc.contributor.authorMacleod, Ruairidh
dc.contributor.authorSchjellerup Jørkov, Marie Louise
dc.contributor.authorDemeter, Fabrice
dc.contributor.authorNovosolov, Maria
dc.contributor.authorSørensen, Lasse
dc.contributor.authorNielsen, Poul Otto
dc.contributor.authorHenriksen, Rasmus H.A.
dc.contributor.authorVimala, Tharsika
dc.contributor.authorMcColl, Hugh
dc.contributor.authorMargaryan, Ashot
dc.contributor.authorIlardo, Melissa
dc.contributor.authorVaughn, Andrew
dc.contributor.authorMortensen, Morten Fischer
dc.contributor.authorNielsen, Anne Birgitte
dc.contributor.authorHede, Mikkel Ulfeldt
dc.contributor.authorRasmussen, Peter
dc.contributor.authorVinner, Lasse
dc.contributor.authorRenaud, Gabriel
dc.contributor.authorStern, Aaron
dc.contributor.authorTheis Zetner Trolle Jensen
dc.contributor.authorJohannsen, Niels Nørkjær
dc.contributor.authorScorrano, Gabriele
dc.contributor.authorSchroeder, Hannes
dc.contributor.authorLysdahl, Per
dc.contributor.author Daisy Ramsøe, Abigail
dc.contributor.authorSkorobogatov, Andrei
dc.contributor.authorSchork, Andrew Joseph
dc.contributor.authorRosengren, Anders
dc.contributor.authorRuter, Anthony
dc.contributor.authorOutram, Alan
dc.contributor.authorTimoshenko, Aleksey
dc.contributor.authorBuzhilova, Alexandra
dc.contributor.authorCoppa, Alfredo
dc.contributor.authorZubova, Alisa
dc.contributor.authorSilva, Ana Maria
dc.contributor.authorHansen, Anders
dc.contributor.authorGromov, Andrey
dc.contributor.authorLogvin, Andrey
dc.contributor.authorGotfredsen, Anne Birgitte
dc.contributor.authorNielsen, Bjarne Henning
dc.contributor.authorGonzález-Rabanal, Borja
dc.contributor.authorLalueza-Fox, Carles
dc.contributor.authorMcKenzie, Catriona
dc.contributor.authorGaunitz, Charleen
dc.contributor.authorBlasco, Concepción
dc.contributor.authorLiesau, Corina
dc.contributor.authorMartinez-Labarga, Cristina
dc.contributor.authorPozdnyakov, Dmitri
dc.contributor.authorCuenca-Solana, David
dc.contributor.authorLordkipanidze, David
dc.contributor.authorEn’shin, Dmitri
dc.contributor.authorSalazar-García, Domingo
dc.contributor.authorPrice, T. Douglas
dc.contributor.authorBorić, Dušan
dc.contributor.authorKostyleva, Elena
dc.contributor.authorVeselovskaya, Elizaveta
dc.contributor.authorUsmanova, Emma
dc.contributor.authorCappellini, Enrico
dc.contributor.authorPetersen, Erik Brinch
dc.contributor.authorKannegaard, Esben
dc.contributor.authorRadina, Francesca
dc.contributor.authorYediay, Fulya Eylem
dc.contributor.authorDuday, Henri
dc.contributor.authorGutiérrez-Zugasti, Igor
dc.contributor.authorPotekhina, Inna
dc.contributor.authorShevnina, Irina
dc.contributor.authorAltinkaya, Isin
dc.contributor.authorGuilaine, Jean
dc.contributor.authorHansen, Jesper
dc.contributor.authorTortosa, Joan Emili Aura
dc.contributor.authorZilhão, João
dc.contributor.authorVega, Jorge
dc.contributor.authorPedersen, Kristoffer Buck
dc.contributor.authorTunia, Krzysztof
dc.contributor.authorZhao, Lei
dc.contributor.authorMylnikova, Liudmila
dc.contributor.authorLarsson, Lars
dc.contributor.authorMetz, Laure
dc.contributor.authorYepiskoposyan, Levon
dc.contributor.authorPedersen, Lisbeth
dc.contributor.authorSarti, Lucia
dc.contributor.authorOrlando, Ludovic
dc.contributor.authorSlimak, Ludovic
dc.contributor.authorKlassen, Lutz
dc.contributor.authorBlank, Malou
dc.contributor.authorGonzález-Morales, Manuel
dc.contributor.authorSilvestrini, Mara
dc.contributor.authorVretemark, Maria
dc.contributor.authorNesterova, Marina
dc.contributor.authorRykun, Marina
dc.contributor.authorRolfo, Mario Federico
dc.contributor.authorSzmyt, Marzena
dc.contributor.authorPrzybyła, Marcin
dc.contributor.authorCalattini, Mauro
dc.contributor.authorSablin, Mikhail
dc.contributor.authorDobisíková, Miluše
dc.contributor.authorMeldgaard, Morten
dc.contributor.authorJohansen, Morten
dc.contributor.authorBerezina, Natalia
dc.contributor.authorCard, Nick
dc.contributor.authorSaveliev, Nikolai
dc.contributor.authorPoshekhonova, Olga
dc.contributor.authorRickards, Olga
dc.contributor.authorLozovskaya, Olga
dc.contributor.authorGábor, Olivér
dc.contributor.authorUldum, Otto Christian
dc.contributor.authorAurino, Paola
dc.contributor.authorKosintsev, Pavel
dc.contributor.authorCourtaud, Patrice
dc.contributor.authorRíos, Patricia
dc.contributor.authorMortensen, Peder
dc.contributor.authorLotz, Per
dc.contributor.authorPersson, Per
dc.contributor.authorBangsgaard, Pernille
dc.contributor.authorDamgaard, Peter de Barros
dc.contributor.authorPetersen, Peter Vang
dc.contributor.authorMartinez, Pilar Prieto
dc.contributor.authorWłodarczak, Piotr
dc.contributor.authorSmolyaninov, Roman
dc.contributor.authorMaring, Rikke
dc.contributor.authorMenduiña, Roberto
dc.contributor.authorBadalyan, Ruben
dc.contributor.authorBadalyan, Ruben
dc.contributor.authorTurin, Ruslan
dc.contributor.authorVasilyiev, Sergey
dc.contributor.authorWåhlin, Sidsel
dc.contributor.authorBorutskaya, Svetlana
dc.contributor.authorSkochina, Svetlana
dc.contributor.authorSørensen, Søren Anker
dc.contributor.authorAndersen, Søren
dc.contributor.authorJørgensen, Thomas
dc.contributor.authorSerikov, Yuri
dc.contributor.authorMolodin, Vyacheslav
dc.contributor.authorSmrcka, Vaclav
dc.contributor.authorMerz, Victor
dc.contributor.authorAppadurai, Vivek
dc.contributor.authorMoiseyev, Vyacheslav
dc.contributor.authorMagnusson, Yvonne
dc.contributor.authorKjær, Kurt
dc.contributor.authorLynnerup, Niels
dc.contributor.authorLawson, Daniel
dc.contributor.authorSudmant, Peter
dc.contributor.authorRasmussen, Simon
dc.contributor.authorKorneliussen, Thorfinn
dc.contributor.authorDurbin, Richard
dc.contributor.authorNielsen, Rasmus
dc.contributor.authorDelaneau, Olivier
dc.contributor.authorWerge, Thomas
dc.contributor.authorRacimo, Fernando
dc.contributor.authorKristiansen, Kristian
dc.contributor.authorWillerslev, Eske
dc.date.accessioned2023-05-02T07:26:26Z
dc.date.available2023-05-02T07:26:26Z
dc.date.issued2022
dc.description.abstractSeveral major migrations and population turnover events during the later Stone Age (after c. 11,000 cal. BP) are believed to have shaped the contemporary population genetic diversity in Eurasia. While the genetic impacts of these migrations have been investigated on regional scales, a detailed understanding of their spatiotemporal dynamics both within and between major geographic regions across Northern Eurasia remains largely elusive. Here, we present the largest shotgun-sequenced genomic dataset from the Stone Age to date, representing 317 primarily Mesolithic and Neolithic individuals from across Eurasia, with associated radiocarbon dates, stable isotope data, and pollen records. Using recent advances, we imputed >1,600 ancient genomes to obtain accurate diploid genotypes, enabling previously unachievable fine-grained population structure inferences. We show that 1) Eurasian Mesolitic hunter-gatherers were more genetically diverse than previously known, and deeply divergent between the west and the east; 2) Hitherto genetically undescribed huntergatherers from the Middle Don region contributed significant ancestry to the later Yamnaya steppe pastoralists; 3) The genetic impact of the transition from Mesolithic hunter-gatherers to Neolithic farmers was highly distinct, east and west of a “Great Divide” boundary zone extending from the Black Sea to the Baltic, with large-scale shifts in genetic ancestry to the west. This include an almost complete replacement of hunter-gatherers in Denmark, but no substantial shifts during the same period further to the east; 4) Within-group relatedness changes substantially during the Neolithic transition in the west, where clusters of Neolithic farmer-associated individuals show overall reduced relatedness, while genetic relatedness remains high until ~4,000 BP in the east, consistent with a much longer persistence of smaller localised hunter-gatherer groups; 5) A fastpaced second major genetic transformation beginning around 5,000 BP, with Steppe-related ancestry reaching most parts of Europe within a 1,000 years span. Local Neolithic farmers admixed with incoming pastoralists in most parts of Europe, whereas Scandinavia experienced another nearcomplete population replacement, with similar dramatic turnover-patterns also evident in western Siberia; 6) Extensive regional differences in the ancestry components related to these early events remain visible to this day, even within countries (research conducted using the UK Biobank resource). Neolithic farmer ancestry is highest in southern and eastern England while Steppe-related ancestry is highest in the Celtic populations of Scotland, Wales, and Cornwall. Overall, our findings show that although the Stone-Age migrations have been important in shaping contemporary genetic diversity in Eurasia, their dynamics and impact were geographically highly heterogeneous.en_US
dc.identifier.citationPopulation Genomics of Stone Age Eurasia / Morten E. Allentoft, Martin Sikora, ... Inna Potekhina [et al.] // BioRxiv. - 2022. - P. 1-52. - https://doi.org/10.1101/2022.05.04.490594en_US
dc.identifier.issn2692-8205
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/25157
dc.identifier.urihttps://doi.org/10.1101/2022.05.04.490594
dc.language.isoenen_US
dc.publisherBioRxiven_US
dc.statusfirst publisheden_US
dc.subjectPopulation genomicsen_US
dc.subjectancient DNAen_US
dc.subjectMesolithicen_US
dc.subjectNeolithicen_US
dc.subjectUK Biobanken_US
dc.subjectarticleen_US
dc.titlePopulation Genomics of Stone Age Eurasiaen_US
dc.typeArticleen_US
dc.typePreprinten_US
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