Models nanocomplexes based on C-60 fullerene for creation of biologically active agents for medicine

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dc.contributor.authorRepetsky, Stanislav
dc.contributor.authorVyshyvana, Iryna
dc.contributor.authorKuznietsova, H.
dc.contributor.authorRybalchenko, V.
dc.contributor.authorKruchinin, Sergei
dc.contributor.authorTykhoniuk, O.
dc.contributor.authorMilokhov, D.
dc.contributor.authorKhilya, O.
dc.contributor.authorMelnyk, Ruslan
dc.date.accessioned2021-03-11T09:20:56Z
dc.date.available2021-03-11T09:20:56Z
dc.date.issued2020
dc.description.abstractComplex drugs based on C60 fullerence and pyrrole derivatives are promising for the development of antitumor and anti-inflammatory agents for use in targeted therapy, but have little efficiency in the synthesis of such complexes and have virtually no stable synthesis products with fullerene. The stability of the nanocomplex based on [60] PCBA and the intermediate compound based on “1H-pyrrole-2,5-dione” effective for the synthesis of targeted therapeutic agents was investigated by means of numerical calculations. The application of quantum-chemical methods in the Gaussian package establishes the stability of the nanocomplex at human body temperatures, the possibility of using such complexes for further study of the therapeutic properties of the individual components of the decomposition products of the nanocomplex.en_US
dc.identifier.citationModels nanocomplexes based on C-60 fullerene for creation of biologically active agents for medicine [electronic resource] / Repetsky S. P., Vyshyvana I. G., Kuznietsova H. M., Rybalchenko V. K., Kruchinin S. P., Tykhoniuk O. I., Milokhov D. S., Khilya O. V., Melnyk R. M. // Modern Physics Letters B. - 2020. - Vol. 34, Issue 19-20, Special Issue. - Article Number 2040064.en_US
dc.identifier.urihttps://doi.org/10.1142/S0217984920400643
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/19608
dc.language.isoenuk_UA
dc.relation.sourceModern Physics Letters B.en_US
dc.statusfirst publisheduk_UA
dc.subjectmodeling of nanocomplexesen_US
dc.subjectquantum-mechanical methodsen_US
dc.subjectantitumor and anti-inflammatory agentsen_US
dc.subjectfullereneen_US
dc.subjectpyrrole derivativeen_US
dc.subjectarticleen_US
dc.titleModels nanocomplexes based on C-60 fullerene for creation of biologically active agents for medicineen_US
dc.typeArticleuk_UA
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