Control of the genotoxicity level of certain mycotoxins by a fiber optical SOS-type biosensor

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dc.contributor.authorStarodub, N.en_US
dc.contributor.authorFedelesh-Morenetz, M.en_US
dc.contributor.authorSavchuk, M.en_US
dc.contributor.authorTaran, O.en_US
dc.contributor.authorNaboka, O.en_US
dc.contributor.authorShuliak, L.en_US
dc.date.accessioned2019-05-29T13:02:05Z
dc.date.available2019-05-29T13:02:05Z
dc.date.issued2018
dc.description.abstractIn addition to their well-known general toxicity, mycotoxins have also been found to often exert genotoxicity. In turn, not only the presence of the mycotoxins is required to be determined, but such DNA-damaging effects by these substances are also needed to be detected in routine monitoring of mycotoxin. The main purpose of this article is to demonstrate the utility of a proposed special fiber optical SOS-chromotest type biosensor, based on the SOS-lux assay in recombinant Escherichia coli cells, in rapid measurement of the genotoxicity level of mycotoxins. The optrode-based fiber optic biosensor and its main operating conditions for such express analysis have been worked out, moreover, its efficacy in the determination of the effects of certain investigated mycotoxins e.g.,T2 mycotoxin, patulin, aflatoxin B2, zearalenone and ochratoxin on the genetic apparatus applied and their activation of the operon of the reparative genes is reported. The genotoxicity of the mycotoxins studied fell in the order: T2 mycotoxin > aflatoxin B2 > patulin >> ochratoxin > zearalenone.en_US
dc.identifier.citationControl of the genotoxicity level of certain mycotoxins by a fiber optical SOS-type biosensor / Starodub N. F., Fedelesh-Morenetz M. I., Savchuk M. V., Taran O. P., Naboka O. I., Shuliak L. N. // World Journal of Engineering Research and Technology. - 2018. - Vol. 4, Issue 6. - P. 199-205.en_US
dc.identifier.urihttps://ekmair.ukma.edu.ua/handle/123456789/15759
dc.language.isoenen_US
dc.relation.sourceWorld Journal of Engineering Research and Technology. - 2018. - Vol. 4, Issue 6en_US
dc.statusfirst publisheden_US
dc.subjectfiber optic-SOS biosensoren_US
dc.subjectmycotoxinen_US
dc.subjectgenotoxicityen_US
dc.subjectdeterminationen_US
dc.subjectarticleen_US
dc.titleControl of the genotoxicity level of certain mycotoxins by a fiber optical SOS-type biosensoren_US
dc.typeArticleen_US
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