Bilko, NadiyaDyagil, IrynaRussu, Iryna2026-02-202026-02-202023Bilko N. M. Estimation of hematopoietic progenitor cells in patients with chronic myeloid leukemia with resistance to tyrosine kinase inhibitors / N. Bilko, I. Dyagil, I. Russu // XXIII. Wilsede Meeting on Modern Trends in Human Leukaemia and Cancer June 24-27, 2023, Wilsede, Germany : abstract book. - [S. l. : s. n.], 2023. - P. 68.https://ekmair.ukma.edu.ua/handle/123456789/38393Chronic myeloid leukemia (CML) is a clonal oncological disease associated with the formation of chimeric bcr-abl gene, the product of which is active BCR-ABL tyrosine kinase playing a major role in the pathogenesis of CML. Data obtained in recent years allowed to assume the decisive role not only of hematopoietic stem cells, but also of bone marrow (BM) progenitor cells in both onset and progression of the disease. However, information on the functional characteristics of BM hematopoietic progenitor cells in different CML phases, in terms of therapeutic inhibition of BCR-ABL tyrosine kinase and the resistance to Imatinib, is not sufficient today and some findings are contradictory. Hence, the aim of this investigation was the estimation of BM hematopoietic progenitor cells in patients with CML with the resistance to tyrosine kinase inhibitors, using in vitro cell culture.enChronic myeloid leukemia (CML)chimeric bcr-ablhematopoietic stem cellsvitro cell cultureconference materialsConference materials