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Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats

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dc.contributor.author Snezhkova, Elisaveta
dc.contributor.author Rodionova, Natalia
dc.contributor.author Bilko, Denys
dc.contributor.author Silvestre-Albero, Joaquín
dc.contributor.author Sydorenko, Alexey
dc.contributor.author Yurchenko, Olga
dc.contributor.author Pakharenko, Marharyta
dc.contributor.author Alavijeh, Mohammad
dc.contributor.author Bardakhivska, Kvitoslava
dc.contributor.author Riabchenko, Natalia
dc.contributor.author Nikolaev, Volodymyr
dc.date.accessioned 2021-11-16T21:41:26Z
dc.date.available 2021-11-16T21:41:26Z
dc.date.issued 2021
dc.identifier.citation Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats [electronic resource] / Snezhkova E., Rodionova N., Bilko D., Silvestre-Albero J., Sydorenko A., Yurchenko O., Pakharenko M., Alavijeh M., Bardakhivska K., Riabchenko N., Nikolaev V. // Applied Sciences : open access journal. - 2021. - Vol. 11, Issue 7. - Article number 3174. en
dc.identifier.uri https://doi.org/10.3390/app11073174
dc.identifier.uri http://ekmair.ukma.edu.ua/handle/123456789/21553
dc.description.abstract Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment. en
dc.language.iso en uk_UA
dc.subject activated charcoal en
dc.subject enterosorbent en
dc.subject acute radiation sickness en
dc.subject rats en
dc.subject article en
dc.title Orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats en
dc.type Article uk_UA
dc.status first published uk_UA
dc.relation.source Applied Sciences : open access journal. ru


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