Treatment Options for Developmental Delay in Children with Perinatal Damage of Nervous System
Loading...
Date
2018
Authors
Sych, Nataliia
Klunnyk, Mariya
Demchuk, Mariya
Ivankova, Olena
Matiyashchuk, Iryna
Sinelnyk, Andriy
Skalozub, Marina
Sorochynska, Khrystyna
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: Improvement of treatment in children with developmental
delay (DD) resulting from perinatal affection of CNS using
combination with conventional therapy and administration of fetal
stem cells (FSCs) in suspensions containing stem cells extracted
from human fetal liver and brain.
Materials and methods: Our study allocated 14 children
diagnosed with developmental delay and perinatal damage of CNS
including 4 boys aged 1.5 to 14 years, with their mean age 4.23 ±
0.31 yrs. and 3 girls - from 3.5 to 13 yrs (mean age – 3.92 ± 0.21
yrs.) (Allocated to the MG) where along with conventional therapy
were administered fetal stem cells. Control group (CG) included
7 patients with Developmental delay (DD) – children treated with
conventional methods only, including 4 males (aged 3 to 14 yrs. and
average age – 4.11 ± 0.14 yrs.) and 3 females (aged from 3 to 15
yrs. and mean age 4.02 ± 0.15 yrs.).
Results: Our research revealed that fetal stem cell therapy,
irrespective of developmental delay severity in children with CNS
damage during perinatal period, can favorably influence the course
of development and their immunological markers in particular.
Procedure of fetal stem cell administration is simple and noninvasive (no potential causes of complications or allergy reactions
in the patients). To promote substantial effects of fetal stem cells
we additionally recommended a complex treatment with medicines;
different supplementary methods were used for the patients. Aspects of
fetal stem cells effect in children with developmental delay are not fully
understood and do need a thorough scientific research. In particular,
future in-depth study is demanded, as well as the larger randomized
and placebo-controlled trials to identify a potential of fetal stem cellsrelated advantages in children with developmental delay (DD).
Conclusion: Fetal stem cells (FSCs) use in complex treatment of
patients with developmental delay tends to improve cognitive functions
along with motor development of children with nervous system
affection; such patients also revealed increased immunology findings.
Description
Keywords
Perinatal damage, Nervous system, Conventional therapy, Mechanotherapy, article
Citation
Treatment Options for Developmental Delay in Children with Perinatal Damage of Nervous System / N. Sych, M. Klunnyk, M. Demchuk [et al.] // Cell Biology: Research & Therapy. - 2018. - Vol. 7, Issue 1. - [5 p.].